Researchers assigned 10 patients (10 eyes) undergoing pars plana vitrectomy to take three 500-mg doses the day before surgery and another dose one hour before surgery. Analysis of vitreous samples taken during surgery showed potentially therapeutic concentrations of the active metabolite penciclovir. Though not necessarily superior to oral valacyclovir or intravenous acyclovir, famciclovir may be a reasonable choice given its favorable pharmacokinetic profile and lower potential toxicity, the authors concluded. American Journal of Ophthalmology, July 2009

Dr Sarbjit Singh
EYE FOR EXCELLENCE

AsianOphthalmology