Low-dose fibrinolytic therapy may improve vision in patients with acute central retinal vein occlusion

Researchers randomized 53 patients with central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) to undergo either thrombolysis with 50 mg of recombinant tissue plasminogen activator (rt-PA) or hemodilution within 11 days of symptom onset. They were followed for one year. Among CRVO patients, median BCVA was 20/60 in the rt-PA group vs. 20/400 in the hemodilution group. Among BRVO patients, there was a tendency for better vision in the rt-PA group, but the difference did not reach statistical significance, possibly due to the smaller subject pool. Retina, July/August 2009

Dr Sarbjit Singh
EYE FOR EXCELLENCE
Comments